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GHS / HazCom term · Glossary

GHS08 (Health Hazard)

Verified vs OSHA sources · 2026-10-05

The GHS hazard pictogram showing a human silhouette with a starburst on the chest. It flags the serious, often long-term health hazards: carcinogenicity, germ cell mutagenicity, reproductive toxicity, respiratory sensitization, specific target organ toxicity (STOT), and aspiration hazard. It's the pictogram for hazards that can cause cancer, organ damage, or lasting harm.

29 CFR 1910.1200 App C

Also known as: health hazard pictogram, serious health hazard symbol

GHS08 (Health Hazard) at a glance

  • Covers the serious/chronic health hazards — the “worst” long-term effects.
  • Includes carcinogens, mutagens, reproductive toxicants, and respiratory sensitizers.
  • Also STOT (single or repeated exposure, Cat 1–2) and aspiration hazard.
  • Respiratory sensitization uses GHS08 (Danger); the milder skin sensitization uses GHS07 (Warning).

In plain English

The “serious long-term harm” symbol — the figure with a star burst on the chest. It flags the scariest slow dangers: cancer, genetic damage, harm to reproduction or a baby, lung allergies, organ damage, and chemicals that can drown your lungs if swallowed.

What the source says, in summary

H350: May cause cancer. H340: May cause genetic defects. H360: May damage fertility or the unborn child. H334: May cause allergy or asthma symptoms … if inhaled. H370: Causes damage to organs. H304: May be fatal if swallowed and enters airways.
OSHA HCS — hazard statements (App C)Summarized, not quoted: read the source for its operative wording.

In context

A classification or labeling concept from the UN Globally Harmonized System, adopted into US law through OSHA's Hazard Communication Standard (29 CFR 1910.1200) and its appendices.

29 CFR 1910.1200

Where this is written in OSHA's rules

Example

Benzene, a known carcinogen, carries the health-hazard pictogram (GHS08) with H350, “May cause cancer.” The same GHS08 appears on a respiratory sensitizer like isocyanates (H334) and on a thin hydrocarbon that's an aspiration hazard (H304).

Why it matters

GHS08 marks the hazards with the highest long-term cost — cancer, organ failure, occupational asthma — often with no immediate symptom to warn the worker. Under-classifying one (using GHS07 where GHS08 belongs) hides a life-altering risk and is a serious HazCom classification violation under 1910.1200.

Health hazard (GHS08) vs. exclamation mark (GHS07)

GHS08 is for serious, usually chronic health effects (cancer, organ damage, respiratory sensitization). GHS07 is for milder, usually reversible effects (irritation, skin allergy, harmful doses). A key split: respiratory sensitization is GHS08/“Danger,” but skin sensitization is GHS07/“Warning.”

Hazards under the health-hazard pictogram (GHS08)

HazardH-code
CarcinogenicityH350 / H351
Germ cell mutagenicityH340 / H341
Reproductive toxicityH360 / H361
Respiratory sensitizationH334
STOT (single/repeated, Cat 1–2)H370–H373
Aspiration hazardH304

GHS08 (Health Hazard): frequently asked questions

What does the health hazard pictogram mean?
It signals serious, often long-term health hazards: carcinogenicity, mutagenicity, reproductive toxicity, respiratory sensitization, specific target organ toxicity (STOT), and aspiration hazard.
How is GHS08 different from the exclamation mark (GHS07)?
GHS08 is for severe, usually chronic effects (cancer, organ damage). GHS07 is for milder, usually reversible effects (irritation, skin allergy, “harmful” doses). Respiratory sensitization is GHS08; skin sensitization is GHS07.
Does GHS08 mean the chemical is immediately dangerous?
Not necessarily — many GHS08 hazards (cancer, organ damage from repeated exposure) develop over time with no immediate symptom, which is exactly why the warning matters.

Related terms

Free tools for this

Governing OSHA standards

More GHS terms

Acute Toxicity

A GHS health-hazard class for the harmful effects that follow a single dose, several doses within 24 hours, or a 4-hour inhalation exposure. Chemicals are sorted into categories by route (oral, dermal, inhalation) using LD50/LC50 cut-offs — Category 1 is the most toxic. OSHA's HazCom standard uses Categories 1–4.

Aspiration Hazard

A GHS health-hazard class for chemicals that can be fatal if swallowed and then enter the airways — directly or by vomiting — causing chemical pneumonia or lung injury. Thin, low-viscosity hydrocarbons (gasoline, kerosene, lamp oil) are the classic example. It is Category 1, with the health-hazard pictogram (GHS08) and signal word “Danger.”

Carcinogenicity

A GHS health-hazard class for chemicals that cause cancer or increase its incidence. GHS (and OSHA's HazCom standard) sorts carcinogens into Category 1A (known human carcinogen), 1B (presumed, from animal evidence), and Category 2 (suspected). Carcinogens carry the health-hazard pictogram (GHS08) and a hazard statement such as H350 (“May cause cancer”).

Chemicals Under Pressure

A physical-hazard class added by OSHA's 2024 HCS update (aligning with GHS Revision 7) for liquids or solids pressurized with a gas, held in pressure receptacles other than aerosol dispensers and not classified as gases under pressure. It is categorized by the flammability of its contents and always carries the gas-cylinder pictogram (GHS04) for the pressure hazard.

Classification

The process of evaluating the available scientific evidence for a chemical against the GHS criteria to decide whether it is hazardous and, if so, the hazard class and category of each effect. Classification is the first step in HazCom — its result determines every label element (pictogram, signal word, hazard and precautionary statements) and SDS content.

Corrosive to Metals

A GHS physical-hazard class for chemicals that, by chemical action, will materially damage or even destroy metals. It is a single category (Category 1), determined by corrosion-rate testing on steel and aluminum, and uses the corrosion pictogram (GHS05) with the hazard statement H290. It is a separate hazard from skin corrosion, even though both use GHS05.

Desensitized Explosives

A physical-hazard class added by OSHA's 2024 HCS update (GHS Revision 7) for solid or liquid explosives that have been phlegmatized — wetted or diluted — to suppress their explosive properties for safe transport and storage. It has four categories based on the corrected burning rate, and uses the flame pictogram (GHS02), not the exploding-bomb.

Globally Harmonized System (GHS)

An internationally agreed framework created by the United Nations (first adopted in 2003) that standardizes how chemical hazards are classified and communicated — using common hazard classes, pictograms, signal words (Danger / Warning), and coded hazard (H) and precautionary (P) statements on labels and safety data sheets. The US adopted GHS into law through OSHA's 2012 Hazard Communication Standard update.

Sources & verification

Reviewed by HazComFast against eCFR, OSHA.gov, NIOSH, and the Federal Register. Last reviewed 2026-10-05. This glossary is general information, not legal advice; OSHA State-Plan states (e.g. California, Michigan) may adopt stricter requirements.

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