What 29 CFR 1910.1450 requires (plain English)
29 CFR 1910.1450, commonly called the OSHA Laboratory standard, applies to employers engaged in the laboratory use of hazardous chemicals: work done on a "laboratory scale" (containers easily handled by one person), with multiple chemicals and procedures, that is not part of a production process. It recognizes that lab work differs fundamentally from industrial chemical use.
The heart of the standard is the Chemical Hygiene Plan: a written program, specific to the laboratory, that sets standard operating procedures, criteria for control measures (such as fume hoods), provisions to ensure fume-hood and protective-equipment performance, information and training, prior-approval requirements, medical consultation, and additional protections for particularly hazardous substances. Employers must designate a Chemical Hygiene Officer, keep exposures below the OSHA limits referenced in the standard, and provide employee training and, where exposure could exceed limits, exposure monitoring.
1910.1450 is a Subpart Z standard. For laboratories, it largely takes the place of the Hazard Communication standard and the substance-specific health standards' exposure-monitoring and medical-surveillance schemes, although certain provisions, such as respirator and specific hazard requirements, still apply.